protein secretion — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TN1877	Lonicerin		Apoptosis , Antibacterial
	Lonicerin has antioxidant, anti-arthritic and antifungal activities, it can result in a combination therapy for the treatment of fungal arthritis due to C. albicans infection.		Apoptosis , Antibacterial
T9349	IXA4		IRE1
	IXA4 is a highly selective, nontoxic activator of IRE1/XBP1s and reduces APP secretion by activating IRE1. IXA4-stimulated IRE1 activation also enhanced pancreatic function.		IRE1
T21623	AS1269574	AS 1269574	GPR , TRP/TRPV Channel
	AS1269574 is a potent, orally available GPR119 agonist. AS1269574(AS 1269574) has the potential for the research of type 2 diabetes.		GPR , TRP/TRPV Channel
T7490	ARN2966		Beta Amyloid
	ARN2966 is an inhibitor of amyloid precursor protein (APP)and amyloid-β (Aβ) secretion.		Beta Amyloid
T19117	3-Deoxyglucosone	3-Deoxy-D-glucosone,2-keto-3-Deoxyglucose	GPX , Glucagon Receptor
	3-Deoxyglucosone(3-Deoxy-D-glucosone) is synthesized by the intermediate pathway of the melad and polyol reactions.3-Deoxyglucosone reacts rapidly with protein amino groups to form advanced glycosylated end proteins (AGE...		GPX , Glucagon Receptor
T22922	Lenalidomide hemihydrate		TNF , Ligand for E3 Ligase , Molecular Glues
	Lenalidomide hemihydrate is a TNF-α secretion inhibitor (IC50 = 13 nM). Lenalidomide hemihydrate could bound endogenous CRBN and recombinant CRBN-DNA damage binding protein-1 (DDB1) complexes.		TNF , Ligand for E3 Ligase , Molecular Glues
T61439	DSS30		Beta Amyloid , BACE , CDK
	DSS30 is a P25/CDK5 inhibitor.DSS30 acts by inhibiting the phosphorylation of amyloid precursor protein cleaving enzyme 1 (BACEl), which reduces the secretion of β-amyloid (Aβ).DSS30 can be used for the prevention and tr...		Beta Amyloid , BACE , CDK
T12781	RV01		Others
	RV01 is a novel quinoline-substituted analogue of resveratrol that inhibits DNA damage, reduces ethanol-induced acetaldehyde dehydrogenase (ALDH2) mRNA expression, and has hydroxyl radical scavenging activity. rV01 reduc...		Others
T11798	L-692429	MK-0751	GHSR , GPCR19
	L-692429 (MK-0751) is a potent nonpeptidyl growth hormone secretagogue (GHS) agonist, a benzolactam derivative, which reverses the inhibition of GH secretion by glucocorticoids.L-692429 has a high affinity for the G prot...		GHSR , GPCR19
TP1516L	C-Reactive Protein (CRP) 77-82 acetate	C-Reactive Protein (CRP) 77-82 acetate(130349-01-8 free base)	Others
	C-Reactive Protein (CRP) 77-82 acetate is the 77-82 fragment of C-Reactive Protein. C-Reactive Protein (CRP), the prototypic marker of inflammation, is a cardiovascular risk marker and may promote atherogenesis.C-reactiv...		Others
T4S0878	Prunetin	Prunusetin	ERK , Dehydrogenase , NF-κB
	1. Prunetin (Prunusetin) significantly reduces serum levels of inflammatory cytokines and mortality in mice challenged with lipopolysaccharide. 2. Prunetin mediates anti-obesity/adipogenesis effects by suppressing obesit...		ERK , Dehydrogenase , NF-κB
T4S0498	Glaucocalyxin A	Wangzaozin B,Leukamenin F	Apoptosis , Akt , Caspase , PI3K
	1. Glaucocalyxin A (Leukamenin F)-SBE-β-CD could be useful with a better solubility and sustained function in drug delivery. 2. Glaucocalyxin A activates caspase-3, decreases BAD phosphorylation, and reduces the expressi...		Apoptosis , Akt , Caspase , PI3K
TP2158	TRV-120027 TFA	TRV-120027 TFA (1234510-46-3 free base)	RAAS , Arrestin
	TRV120027 TFA is a β-arrestin-1-biased agonist of the angiotensin II receptor type 1 (AT1R) and engages ß-arrestins while blocking G-protein signaling.		RAAS , Arrestin
T9857	Vasopressin	antidiuretic hormone (ADH),argipressin,arginine vasopressin (AVP)	Endogenous Metabolite
	Vasopressin (argipressin), a cyclic nine-peptide synthesized by hypothalamic neurons, is one of the hormones involved in peptide prohormone synthesis. Vasopressin is involved in the regulation process of hypothalamic-pit...		Endogenous Metabolite
T29701	AG 85	AG85,AG-85
	AG 85 is a major secretion protein of Mycobacterium tuberculosis.
T40145	Sec61-IN-3	Sec61-IN-3
	Sec61-IN-2 (A3) is a protein secretion inhibitor.
T40147	Sec61-IN-2	Sec61-IN-2
	Sec61-IN-2 (A347) is a protein secretion inhibitor.
T11846	LHVS		Cysteine Protease
	LHVS effectively blocks T. gondii microneme protein secretion (IC50=10 μM), gliding motility, and cell invasion. LHVS is a potent, non-selective cysteine protease inhibitor.		Cysteine Protease
T68573	Tigapotide triflutate
	Tigapotide triflutate is a synthetic peptide corresponding to amino acids 31-45 of PSP94 (prostate secretory protein) that inhibits matrix metalloproteinase-9 secretion.
T68574	Tigapotide Free Base
	Tigapotide Free Base is a synthetic peptide corresponding to amino acids 31-45 of PSP94 (prostate secretory protein) that inhibits matrix metalloproteinase-9 secretion.